反应详情

An amount of 2.3 g (6 m mole) of 2-benzyloxy-7,8,9,10-tetrahydro-10-oxo-11-phenyl-6H-azepino[1,2-a]indole 4.5 ml of 80% hydrazine hydrate and 1.5 g of potassium hydroxide were heated in 6 ml of triethylene-glycol for two hours to 180° C. and for four hours to 220° C. After cooling, the reaction mixture was mixed with water and extracted with chloroform. After evaporation of the chloroform extracts, the residue was purified by column chromatography on silicagel (solvent: toluene). When the eluates were evaporated, colorless crystals were obtained.

1. temperatureAfter cooling
2. extractionextracted with chloroform
3. customAfter evaporation of the chloroform
4. customthe residue was purified by column chromatography on silicagel (solvent: toluene)
5. customWhen the eluates were evaporated
6. customcolorless crystals were obtained