Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 66829Generated: October 29, 2026

Hydrogen Bromide → 3-Methyl-2-(4-nitro-phenyl)-1-propyl-1H-indole-5-ol

https://huagongshe.com/reaction/66829

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrogen BromideHCID 260—
ReactantHCID 20529107HCID 20529107—
SolventAcetic AcidHCID 176—
Product3-Methyl-2-(4-nitro-phenyl)-1-propyl-1H-indole-5-olHCID 20529108—

Reaction Steps

Four grams (10 m mole) of 5-benzyloxy-3-methyl-2-(4-nitro-phenyl)-1-propyl-1H-indole and 40 ml of a saturated solution of hydrogen bromide in glacial acetic acid were refluxed for 20 minutes. After evaporation, the residue was purified by chromatography on silicagel (solvent: toluene/acetone (20:1)).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04343811
Source datasetuspto-grants-1982_08
ORD IDord-6ad4afb5c08c47588b1e1407a2aab92d
Source noteuspto-grants-1982_08