Ethylene Glycol → 2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)-7-chlorothieno[3,2-b]pyridine

HRID 668893Notes

Reaction equation

HRID 668893 reaction equation
[C:23]12([CH2:24][S:25]([OH:26])(=[O:27])=[O:28])[C:29]([CH3:30])([CH3:31])[CH:32]([CH2:33][CH2:34]1)[CH2:35][C:36]2=[O:37].[CH3:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1.[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][cH:7]1)[cH:8][c:9](-[c:11]1[n:12][cH:13][c:14]([CH:15]=[O:16])[cH:17][cH:18]1)[s:10]2.[OH:19][CH2:20][CH2:21][OH:22]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][cH:7]1)[cH:8][c:9](-[c:11]1[n:12][cH:13][c:14]([CH:15]3[O:16][CH2:21][CH2:20][O:19]3)[cH:17][cH:18]1)[s:10]2

Participants

5

Reactant 4

HCID 174Ethylene GlycolHCID 1140TolueneHCID 18462Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)-HCID 579196526-(7-Chlorothieno[3,2-b]pyridin-2-yl)nicotinaldehyde

Product 1

HCID 579195542-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)-7-chlorothieno[3,2-b]pyridine

Sources & evidence

ORD record
ord-37a0c029d38a4ed89be4e48962c3854e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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