HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-[3-(2-Methoxy-phenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methyl-propanic acid methylester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-bromo-2-methylpropionate | HCID 90097 | — |
| Reactant | HCID 20529172 | HCID 20529172 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-[3-(2-Methoxy-phenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methyl-propanic acid methylester | HCID 53844870 | — |
Reaction Steps
A mixture of 5.34 g (0.02 mole) of 3-(2-methoxy-phenyl)-1,2-dimethyl-1H-indole-5-ol, 5.4 g (0.03 mole) of 2-bromo-2-methyl-propanoic acid methylester, and 14 g (0.1 mole) of potassium carbonate was refluxed for 16 hours in 250 ml of methyl-ethylketone. The precipitate was filtered off, the filtrate was evaporated, and the residue obtained was chromatographed on silicagel (solvent: toluene/acetone (30:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04343811 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-83a8447f5952414c8ba7093c568d65f8 |
| Source note | uspto-grants-1982_08 |