反应详情

One gram (2.53 m mole) of 2-[2-(4-amino-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester and 0.25 g (2.5 m mole) of triethylamine were dissolved in 15 ml of chloroform and 0.2 g (2.55 m mole) of acetyl chloride were added dropwise while ice-cooling. After a few hours at room temperature the reaction mixture was mixed with water and extracted with chloroform. The chloroform extracts were dried and evaporated, and the residue was purified by chromatography on silicagel (solvent: toluene/acetone (5:1)).

1. temperaturecooling
2. extractionextracted with chloroform
3. dry with materialThe chloroform extracts were dried
4. customevaporated
5. customthe residue was purified by chromatography on silicagel (solvent: toluene/acetone (5:1))