反应详情

A suspension of 1.0 g (2.6 m mole) of 2-methyl-2-[2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-5-yloxy]propanoic acid hydrochloride was added dropwise to 1.0 g (26 m mole) of lithiumaluminium hydride in 50 ml of absolute tetrahydrofurane under stirring. After the mixture was stirred for one hour at 60° C., 2 N sodium hydroxide solution was added. The sodium aluminate precipitate was filtered off, and the residue was evaporated and purified on silicagel by colunn chromatography (eluant: ethyl acetate).

1. stirringAfter the mixture was stirred for one hour at 60° C.
2. filtrationThe sodium aluminate precipitate was filtered off
3. customthe residue was evaporated
4. custompurified on silicagel by colunn chromatography (eluant: ethyl acetate)