Nitrogen → 6-[Amino-(6-Chloro-Pyridin-3-yl)-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-4-(3-Chloro-Phenyl)-1-Methyl-1H-Quinolin-2-One

HRID 669305Notes

Reaction equation

HRID 669305 reaction equation
[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10](=[O:34])[n:11]([CH3:33])[c:12]3[cH:13][cH:14][c:15]([C:18]([c:19]4[n:20]([CH3:24])[cH:21][n:22][cH:23]4)([OH:25])[c:26]4[cH:27][n:28][c:29]([Cl:32])[cH:30][cH:31]4)[cH:16][c:17]23)[cH:5][cH:6][cH:7]1.[N:35]#[N:36].[S:37]([Cl:38])([Cl:39])=[O:40]>>[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10](=[O:34])[n:11]([CH3:33])[c:12]3[cH:13][cH:14][c:15]([C:18]([c:19]4[n:20]([CH3:24])[cH:21][n:22][cH:23]4)([c:26]4[cH:27][n:28][c:29]([Cl:32])[cH:30][cH:31]4)[NH2:35])[cH:16][c:17]23)[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 947NitrogenHCID 24386Thionyl ChlorideHCID 111793634-(3-Chloro-phenyl)-6-[(6-chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-1H-quinolin-2-one

Product 1

HCID 112488556-[Amino-(6-Chloro-Pyridin-3-yl)-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-4-(3-Chloro-Phenyl)-1-Methyl-1H-Quinolin-2-One

Sources & evidence

ORD record
ord-c8599fbdba6b46a99f30bd6092e1a858
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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