Tetrahydrofuran → N-[4-(4,5-dichloro-2-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide
Reaction equation
[C:1]([CH:2]=[CH2:3])(=[O:4])[Cl:5].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[NH2:6][c:7]1[cH:8][c:9]2[c:10]([NH:27][c:28]3[cH:29][c:30]([Cl:36])[c:31]([Cl:35])[cH:32][c:33]3[F:34])[n:11][cH:12][n:13][c:14]2[cH:15][c:16]1[O:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1>>[C:1]([CH:2]=[CH2:3])(=[O:4])[NH:6][c:7]1[cH:8][c:9]2[c:10]([NH:27][c:28]3[cH:29][c:30]([Cl:36])[c:31]([Cl:35])[cH:32][c:33]3[F:34])[n:11][cH:12][n:13][c:14]2[cH:15][c:16]1[O:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1Participants
4
Sources & evidence
- ORD record
- ord-e4e0f93287794940a47847cfac007abf
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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