反应详情

A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 16.0 g (0.1 mole) 2-fluorobenzoyl chloride in 250 ml xylene was heated at reflux for 20 hours. After filtration of the reaction mixture, the filtrate was concentrated to 30 ml whereupon a precipitation resulted. The precipitate was removed by filtration and recrystallized from benzene to give 3.4 g (10% yield) of pure product; m.p. 149° C.

1. temperatureat reflux for 20 hours
2. filtrationAfter filtration of the reaction mixture
3. concentrationthe filtrate was concentrated to 30 ml whereupon a precipitation
4. customresulted
5. customThe precipitate was removed by filtration
6. customrecrystallized from benzene