2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → 1-(2-Fluoro-5-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(3-oxo-3,4-dihydro pyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

HRID 669558Notes

Reaction equation

HRID 669558 reaction equation
[F:21][c:22]1[c:23]([N:32]=[C:33]=[O:34])[cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]1.[NH2:1][c:2]1[c:3]([F:20])[cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][n:10][c:11]3[nH:12][c:13](=[O:17])[cH:14][n:15][c:16]23)[cH:18][cH:19]1>>[NH:1]([c:2]1[c:3]([F:20])[cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][n:10][c:11]3[nH:12][c:13](=[O:17])[cH:14][n:15][c:16]23)[cH:18][cH:19]1)[C:33]([NH:32][c:23]1[c:22]([F:21])[cH:27][cH:26][c:25]([C:28]([F:29])([F:30])[F:31])[cH:24]1)=[O:34]

Participants

3

Reactant 2

HCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 469009328-(4-amino-3-fluorophenoxy)pyrido[2,3-b]pyrazin-3(4H)-one

Product 1

HCID 441339141-(2-Fluoro-5-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(3-oxo-3,4-dihydro pyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

Sources & evidence

ORD record
ord-44ed9307f574477c90aca319360fca82
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…