Dichloromethane → HCID 86638552, compound

HRID 669998Notes

Reaction equation

HRID 669998 reaction equation
[C:45]([CH3:46])([CH3:47])([CH3:48])[Si:49]([Cl:50])([CH3:51])[CH3:52].[Cl:53][CH2:54][Cl:55].[N:1]12[CH2:2][CH2:3][CH2:4][N:5]=[C:6]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]2.[NH2:12][c:13]1[c:14]([Cl:44])[cH:15][c:16]([C:19](=[O:20])[N:21]2[CH2:22][CH2:23][N:24]([CH2:27][c:28]3[cH:29][cH:30][c:31]([C:34]([C:35]([F:36])([F:37])[F:38])([C:39]([F:40])([F:41])[F:42])[OH:43])[cH:32][cH:33]3)[CH2:25][CH2:26]2)[cH:17][cH:18]1>>[NH2:12][c:13]1[c:14]([Cl:44])[cH:15][c:16]([C:19](=[O:20])[N:21]2[CH2:22][CH2:23][N:24]([CH2:27][c:28]3[cH:29][cH:30][c:31]([C:34]([C:35]([F:36])([F:37])[F:38])([C:39]([F:40])([F:41])[F:42])[O:43][Si:49]([C:45]([CH3:46])([CH3:47])[CH3:48])([CH3:51])[CH3:52])[cH:32][cH:33]3)[CH2:25][CH2:26]2)[cH:17][cH:18]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 28928tert-Butyldimethylsilyl chlorideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 86638551(4-Amino-3-chlorophenyl)(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazin-1-yl)methanone

Product 1

HCID 86638552HCID 86638552, compound

Sources & evidence

ORD record
ord-51aa7c1b8b3143699a079e2cfdc624f4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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