Methanol → 3-chloro-4-fluoro-N-(3-hydroxy-4-methyl-phenyl)-benzamide

HRID 670456Notes

Reaction equation

HRID 670456 reaction equation
[CH3:37][OH:38].[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[NH:7][c:8]2[cH:9][cH:10][c:11]([CH3:25])[c:12]([O:14][C:15](=[O:16])[c:17]3[cH:18][cH:19][c:20]([F:21])[c:22]([Cl:23])[cH:24]3)[cH:13]2)[cH:26][cH:27][c:28]1[F:29].[Na+:31].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1.[OH-:30]>>[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[NH:7][c:8]2[cH:9][cH:10][c:11]([CH3:25])[c:12]([OH:14])[cH:13]2)[cH:26][cH:27][c:28]1[F:29]

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 8028TetrahydrofuranHCID 672127893-Chloro-4-fluoro-benzoic acid 5-(3-chloro-4-fluoro-benzoylamino)-2-methyl-phenyl ester

Product 1

HCID 575815783-chloro-4-fluoro-N-(3-hydroxy-4-methyl-phenyl)-benzamide

Sources & evidence

ORD record
ord-3e762c61c2ad49d99b458e774d272394
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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