Sodium borohydride → HCID 12797987, compound

HRID 67073Notes

Reaction equation

HRID 67073 reaction equation
[CH2:1]1[O:29][C:28]2[CH:27]=[CH:26][C:5]([C:6]([CH2:8][N:9]3[CH2:14][CH2:13][CH:12]([N:15]4[CH2:24][C:23]5[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=5)[NH:17][C:16]4=[O:25])[CH2:11][CH2:10]3)=[O:7])=[CH:4][C:3]=2[O:2]1.[BH4-].[Na+]>>[CH2:1]1[O:29][C:28]2[CH:27]=[CH:26][C:5]([CH:6]([OH:7])[CH2:8][N:9]3[CH2:10][CH2:11][CH:12]([N:15]4[CH2:24][C:23]5[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=5)[NH:17][C:16]4=[O:25])[CH2:13][CH2:14]3)=[CH:4][C:3]=2[O:2]1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 127979851-(3,4-methylenedioxybenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

Product 1

HCID 12797987HCID 12797987, compoundYield 67.8%

Procedure

In this example, the procedure of Example 3 is repeated except that 2.2 g of 1-(3,4-methylenedioxybenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine and 410 mg of sodium borohydride are used to obtain 1.69 g of a crude product. The crude product is recrystallized from hot ethanol to obtain 1.50 g of the desired product.

Workup

  1. customto obtain 1.69 g of a crude product
  2. customThe crude product is recrystallized from hot ethanol

Sources & evidence

ORD record
ord-60febbc6e4eb4d87bff29adb7f125753
Source dataset
uspto-grants-1982_08
Patent number
US04344948

Reaction notes

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