反应详情

In this example, 4.00 g 4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine mono-hydrochloride, 3.44 g of α-bromo-p-methoxyacetophenone, 4.2 ml of triethylamine and 60 ml of methanol are mixed and stirred at room temperature overnight. Then, the white crystals deposited are separated by filtration, successively washed with methanol and water and dried to obtain 4.71 g of a crude product. The crude product is recrystallized from a mixed solvent of chloroform and ethanol to obtain 3.79 g of the desired product.

1. customThen, the white crystals deposited are separated by filtration
2. washsuccessively washed with methanol and water
3. customdried
4. customto obtain 4.71 g of a crude product
5. customThe crude product is recrystallized from a mixed solvent of chloroform and ethanol