反应详情

In this reference example, to the mixture of 23.0 g of 1-benzyl-4-[N-(o-aminomethylphenyl)-amino]-piperidine and 200 ml of acetonitrile, 17.4 g of 1,1'-carbonyldiimidazole is added over a period of 3 hours with stirring at 40° to 60° C. Then, the resultant mixture is refluxed with heating for one hour, brought back to room temperature and stirred at room temperature for 2 hours. The crystals deposited are separated by filtration, successively washed with water and methanol and dried to obtain 16.8 g of a crude product. The crude product is recrystallized from methanol to obtain 12.18 g of the desired product.

1. additionis added over a period of 3 hours
2. temperaturewith heating for one hour
3. custombrought back to room temperature
4. stirringstirred at room temperature for 2 hours
5. customThe crystals deposited are separated by filtration
6. washsuccessively washed with water and methanol
7. customdried
8. customto obtain 16.8 g of a crude product
9. customThe crude product is recrystallized from methanol