Acetone → 2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenylamino)-4-(4-fluorophenyl)-4,5-dihydrobenzo[d]thiazol-6(7H)-one

HRID 670865Notes

Reaction equation

HRID 670865 reaction equation
[CH3:37][C:38](=[O:39])[CH3:40].[Cl:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[c:8]([O:34][CH3:35])[cH:9][c:10]([NH:13][c:14]3[s:15][c:16]4[c:17]([n:18]3)[CH:19]([c:27]3[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]3)[CH2:20][C:21]3([CH2:22]4)[O:23][CH2:26][CH2:25][O:24]3)[cH:11][cH:12]2)[cH:6]1.[ClH:36]>>[Cl:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[c:8]([O:34][CH3:35])[cH:9][c:10]([NH:13][c:14]3[s:15][c:16]4[c:17]([n:18]3)[CH:19]([c:27]3[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]3)[CH2:20][C:21](=[O:23])[CH2:22]4)[cH:11][cH:12]2)[cH:6]1

Participants

4

Reactant 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 46864555N-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-4-(4-fluorophenyl)-5,7-dihydro-4H-spiro[benzo[d]thiazole-6,2'-[1,3]dioxolan]-2-amine

Product 1

HCID 581100012-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenylamino)-4-(4-fluorophenyl)-4,5-dihydrobenzo[d]thiazol-6(7H)-one

Sources & evidence

ORD record
ord-ead378902d3d4ac491aed39fa84e6655
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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