Water → 2-(Diethylamino-acetylamino)-6-(chloroacetylamino)-benzo[1,2-d:5,4-d']bisthiazole

HRID 67106Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 67106
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH2:6]([N:8]([N:11]([C:25](=[O:27])[CH3:26])[C:12]1[S:13][C:14]2[C:15](=[CH:17][C:18]3[N:19]=[C:20]([NH2:24])[S:21][C:22]=3[CH:23]=2)[N:16]=1)[CH2:9][CH3:10])[CH3:7].O.N1C=CC=CC=1>CN(C)C=O>[CH2:6]([N:8]([N:11]([C:25](=[O:27])[CH3:26])[C:12]1[S:13][C:14]2[C:15](=[CH:17][C:18]3[N:19]=[C:20]([NH:24][C:3](=[O:4])[CH2:2][Cl:1])[S:21][C:22]=3[CH:23]=2)[N:16]=1)[CH2:9][CH3:10])[CH3:7]

Komponenten

6

Edukt 4

HCID 962WaterHCID 1049PyridineHCID 6577Chloroacetyl chlorideHCID 867385292-(Diethylamino-acetylamino)6-amino-benzo[1,2-d:5,4-d']bisthiazole

Produkt 1

HCID 867385302-(Diethylamino-acetylamino)-6-(chloroacetylamino)-benzo[1,2-d:5,4-d']bisthiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

500 mgm of chloroacetyl chloride were added to a stirred solution of 950 gm of 2-(diethylamino-acetylamino)6-amino-benzo[1,2-d:5,4-d']bisthiazole in 5 ml of dimethylformamide at 0° to 5° C. The mixture was heated for 30 minutes on a waterbath, then cooled, admixed with 50 ml of water and made alkaline with pyridine. The resulting precipitate was collected, washed and recrystallized from dimethylformamide.

Aufarbeitung

  1. temperatureThe mixture was heated for 30 minutes on a waterbath
  2. temperaturecooled
  3. customThe resulting precipitate was collected
  4. washwashed
  5. customrecrystallized from dimethylformamide

Quellen und Nachweise

ORD-Eintrag
ord-c4baac9bbe744accbb68142065b01f91
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04344946

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