反应详情

11 g of 4-chloro-3-nitro-benzophenone, 20 g of methylamine, 153.4 g of methanol and 27.5 g of sulpholane are warmed to 125° for 15 hours in a closed vessel. The reaction solution is evaporated to dryness, the residue is boiled thoroughly with 400 ml of 2 N hydrochloric acid for 20 minutes and the precipitate is filtered off, washed with water and dissolved in methylene chloride. After drying over sodium sulphate and evaporating, 4-methylamino-3-nitro-benzophenone with a melting point of 198°-201° is obtained.

1. customThe reaction solution is evaporated to dryness
2. filtrationthe precipitate is filtered off
3. washwashed with water
4. dissolutiondissolved in methylene chloride
5. dry with materialAfter drying over sodium sulphate
6. customevaporating