Sodium ion → 4-tert.-butyl-N-[6-(4-(5-bromo-2-pyrimidinyloxy)-2-butynyloxy)-5-(o-methoxy-phenoxy)-4-pyrimidinyl]-benzene sulfonamide

HRID 672585Notes

Reaction equation

HRID 672585 reaction equation
[Br:38][c:39]1[cH:40][n:41][c:42]([Cl:45])[n:43][cH:44]1.[C:3]([CH3:4])([CH3:5])([CH3:6])[c:7]1[cH:8][cH:9][c:10]([S:13](=[O:14])(=[O:15])[NH:16][c:17]2[n:18][cH:19][n:20][c:21]([O:32][CH2:33][C:34]#[C:35][CH2:36][OH:37])[c:22]2[O:23][c:24]2[c:25]([O:30][CH3:31])[cH:26][cH:27][cH:28][cH:29]2)[cH:11][cH:12]1.[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[H-:1].[Na+:2]>>[C:3]([CH3:4])([CH3:5])([CH3:6])[c:7]1[cH:8][cH:9][c:10]([S:13](=[O:14])(=[O:15])[NH:16][c:17]2[n:18][cH:19][n:20][c:21]([O:32][CH2:33][C:34]#[C:35][CH2:36][O:37][c:42]3[n:41][cH:40][c:39]([Br:38])[cH:44][n:43]3)[c:22]2[O:23][c:24]2[c:25]([O:30][CH3:31])[cH:26][cH:27][cH:28][cH:29]2)[cH:11][cH:12]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 8028TetrahydrofuranHCID 166653HydrideHCID 6066655-Bromo-2-chloropyrimidineHCID 101852334-tert-Butyl-N-[6-(4-hydroxy-but-2-ynyloxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide

Product 1

HCID 101684964-tert.-butyl-N-[6-(4-(5-bromo-2-pyrimidinyloxy)-2-butynyloxy)-5-(o-methoxy-phenoxy)-4-pyrimidinyl]-benzene sulfonamide

Sources & evidence

ORD record
ord-1c44cb9c8dfb4b4fb7cb7745a7386fec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…