反应详情

温度

5 °C

To a mixture of 3.78 g (0.025 mol) 4-carbomethoxy aniline and 10 ml of 12 N hydrochloric acid in 15 ml of water, cooled to 5° C., there is added dropwise a solution of 1.9 g (0.0275 mol) sodium nitrite in 5 ml of water. The solution formed is added to an ice cooled solution of 3.15 g (0.025 mol) 4-hydroxy-6-methyl pyr-2-one and 11 g (0.1025 mol) sodium carbonate in 65 ml of water. The suspension formed is stirred at 5° C. for 1 hr and at room temperature for 3 hrs. The suspension is vacuum filtered and the filter cake is air dried to afford 6.8 g (94.4% yield) of product, mp 230-240 decomp.

1. customThe solution formed
2. customThe suspension formed
3. filtrationfiltered
4. customdried