Potassium Cation → Tert-butyl 4-[4-(2,3-difluorophenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate

HRID 672920Notes

Reaction equation

HRID 672920 reaction equation
[Br:1][c:2]1[s:3][cH:4][c:5](-[c:7]2[c:8]([F:14])[c:9]([F:13])[cH:10][cH:11][cH:12]2)[n:6]1.[C:28](=[O:29])([O-:30])[O-:31].[CH3:35][N:36]([CH3:37])[CH:38]=[O:39].[K+:32].[K+:33].[N:15]1([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1.[OH2:34]>>[c:2]1([N:18]2[CH2:17][CH2:16][N:15]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:20][CH2:19]2)[s:3][cH:4][c:5](-[c:7]2[c:8]([F:14])[c:9]([F:13])[cH:10][cH:11][cH:12]2)[n:6]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 143452tert-Butyl piperazine-1-carboxylateHCID 687769562-Bromo-4-(2,3-difluorophenyl)-1,3-thiazole

Product 1

HCID 68781293Tert-butyl 4-[4-(2,3-difluorophenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate

Sources & evidence

ORD record
ord-11bc91460c2548689fc8a25c0050df64
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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