Potassium Cation → 6-Fluoro-2-(oxiran-2-yl)chroman

HRID 673680Notes

Reaction equation

HRID 673680 reaction equation
[C:33](=[O:34])([O-:35])[O-:36].[CH3:42][OH:43].[Cl:39][CH2:40][Cl:41].[F:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[O:8][CH:7]([CH:12]([CH2:13][OH:14])[OH:15])[CH2:6][CH2:5]2.[K+:37].[K+:38].[OH2:44].[S:22]([Cl:23])([c:24]1[cH:25][cH:26][c:27]([CH3:28])[cH:29][cH:30]1)(=[O:31])=[O:32].[cH:16]1[cH:17][cH:18][n:19][cH:20][cH:21]1>>[F:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[O:8][CH:7]([CH:12]1[CH2:13][O:15]1)[CH2:6][CH2:5]2

Participants

9

Reactant 8

HCID 813Potassium Cation2×HCID 887MethanolHCID 962WaterHCID 1049PyridineHCID 6344DichloromethaneHCID 73974-Toluenesulfonyl chlorideHCID 19660Carbonate IonHCID 44631567Nebivolol Impurity 32

Product 1

HCID 116584396-Fluoro-2-(oxiran-2-yl)chroman

Sources & evidence

ORD record
ord-41e4e8420d664714af4556eb5fd32ed9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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