Dichloromethane → 2-Bromo-1-[(3SR,4RS)-3-[(RS)-1 (5-chloro-pyridin-2-yloxy)-ethyl]-4-(3,4-dichloro-phenyl)-pyrrolidin-1-yl]-ethanone

HRID 673741Notes

Reaction equation

HRID 673741 reaction equation
[Br:31][CH2:32][C:33](=[O:34])[Cl:35].[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:8][CH:9]([CH3:10])[CH:11]2[CH2:12][NH:13][CH2:14][CH:15]2[c:16]2[cH:17][c:18]([Cl:23])[c:19]([Cl:22])[cH:20][cH:21]2)[n:6][cH:7]1.[Cl:36][CH2:37][Cl:38]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:8][CH:9]([CH3:10])[CH:11]2[CH2:12][N:13]([C:33]([CH2:32][Br:31])=[O:34])[CH2:14][CH:15]2[c:16]2[cH:17][c:18]([Cl:23])[c:19]([Cl:22])[cH:20][cH:21]2)[n:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 89602Bromoacetyl chlorideHCID 669991845-Chloro-2-{(RS)-1-[(3SR,4RS)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethoxy}-pyridine

Product 1

HCID 673278832-Bromo-1-[(3SR,4RS)-3-[(RS)-1 (5-chloro-pyridin-2-yloxy)-ethyl]-4-(3,4-dichloro-phenyl)-pyrrolidin-1-yl]-ethanone

Sources & evidence

ORD record
ord-580a4dc440eb4d178d345b590f33e588
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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