Formaldehyde → 5-Chloro-1-(4-fluorophenyl)-3-[1-[2-(3-hydroxymethyl-2-imidazolidinon-1-yl)ethyl]-4-piperidyl]-1H-indole

HRID 673791Notes

Reaction equation

HRID 673791 reaction equation
[CH2:32]=[O:33].[Cl:1][c:2]1[cH:3][c:4]2[c:5]([CH:18]3[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][N:26]4[C:27](=[O:31])[NH:28][CH2:29][CH2:30]4)[CH2:22][CH2:23]3)[cH:6][n:7](-[c:11]3[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]3)[c:8]2[cH:9][cH:10]1.[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([CH:18]3[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][N:26]4[C:27](=[O:31])[N:28]([CH2:32][OH:33])[CH2:29][CH2:30]4)[CH2:22][CH2:23]3)[cH:6][n:7](-[c:11]3[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]3)[c:8]2[cH:9][cH:10]1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 8028TetrahydrofuranHCID 60149Sertindole

Product 1

HCID 199276205-Chloro-1-(4-fluorophenyl)-3-[1-[2-(3-hydroxymethyl-2-imidazolidinon-1-yl)ethyl]-4-piperidyl]-1H-indole

Sources & evidence

ORD record
ord-622dbd4eba364005a1acf788fb17c069
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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