Dichloromethane → 1-[5-Aminomethyl-1-(4-hydroxy-butyl)-1H-benzoimidazol-2-ylmethyl]-4-methoxy-1H-quinolin-2-one

HRID 674601Notes

Reaction equation

HRID 674601 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH2:8][c:9]1[cH:10][c:11]2[c:12]([n:13]([CH2:30][CH2:31][CH2:32][CH2:33][OH:34])[c:14]([CH2:16][n:17]3[c:18](=[O:29])[cH:19][c:20]([O:27][CH3:28])[c:21]4[cH:22][cH:23][cH:24][cH:25][c:26]34)[n:15]2)[cH:35][cH:36]1)([CH3:5])([CH3:6])[CH3:37].[Cl:45][CH2:46][Cl:47].[F:38][C:39]([F:40])([F:41])[C:42]([OH:43])=[O:44]>>[NH2:7][CH2:8][c:9]1[cH:10][c:11]2[c:12]([n:13]([CH2:30][CH2:31][CH2:32][CH2:33][OH:34])[c:14]([CH2:16][n:17]3[c:18](=[O:29])[cH:19][c:20]([O:27][CH3:28])[c:21]4[cH:22][cH:23][cH:24][cH:25][c:26]34)[n:15]2)[cH:35][cH:36]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 69717811[1-(4-hydroxy-butyl)-2-(4-methoxy-2-oxo-2H-quinolin-1-ylmethyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester

Product 1

HCID 444336091-[5-Aminomethyl-1-(4-hydroxy-butyl)-1H-benzoimidazol-2-ylmethyl]-4-methoxy-1H-quinolin-2-one

Sources & evidence

ORD record
ord-b02d5725a9c044fd8cd542956edff59d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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