Acetonitrile → 6-(2-Pyrimidinyl)-5-hexyn-1-ol

HRID 674712Notes

Reaction equation

HRID 674712 reaction equation
[Br:1][c:2]1[n:3][cH:4][cH:5][cH:6][n:7]1.[CH2:8]([CH2:9][CH2:10][CH2:11][C:12]#[CH:13])[OH:14].[CH3:30][C:31]#[N:32].[CH:15]1([NH:16][CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1.[Cu:28][I:29]>>[c:2]1([C:13]#[C:12][CH2:11][CH2:10][CH2:9][CH2:8][OH:14])[n:3][cH:4][cH:5][cH:6][n:7]1

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 7582DicyclohexylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 702345-Hexyn-1-olHCID 783452-Bromopyrimidine

Product 1

HCID 198767486-(2-Pyrimidinyl)-5-hexyn-1-ol

Sources & evidence

ORD record
ord-72bfbcee20574ba480d34a63d3ed3e58
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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