反应详情

Methylamine in methanol (2 M, 20 mL) was added to 2-acetyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride (2 g). The mixture was stirred at rt for 16 h. Excess methylamine and methanol were evaporated under vacuum and hydrochloric acid (10%, 30 mL) was added to the residue. The mixture was heated at reflux for 3 h and the aqueous solution was evaporated under vacuum. The residue was trituiated with ethyl acetate (2×20 mL) to afford 7-methylaminosulfonyl-1,2,3,4-tetrahydro-isoquinoline hydrochloride (1.9 g).

1. customExcess methylamine and methanol were evaporated under vacuum and hydrochloric acid (10%, 30 mL)
2. additionwas added to the residue
3. temperatureThe mixture was heated
4. temperatureat reflux for 3 h
5. customthe aqueous solution was evaporated under vacuum