Bromoform → 5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[5-bromo-2-(2-chloro-5-propan-2-ylphenyl)phenyl]methyl]-4-methyl-1,3-oxazolidin-2-one

HRID 676264Notes

Reaction equation

HRID 676264 reaction equation
[CH:47]([Br:48])([Br:49])[Br:50].[Cl:51][CH2:52][Cl:53].[N:40]([O:41][C:42]([CH3:43])([CH3:44])[CH3:45])=[O:46].[NH2:1][c:2]1[cH:3][c:4]([CH2:18][N:19]2[C:20](=[O:39])[O:21][CH:22]([c:25]3[cH:26][c:27]([C:35]([F:36])([F:37])[F:38])[cH:28][c:29]([C:31]([F:32])([F:33])[F:34])[cH:30]3)[CH:23]2[CH3:24])[c:5](-[c:8]2[c:9]([Cl:17])[cH:10][cH:11][c:12]([CH:14]([CH3:15])[CH3:16])[cH:13]2)[cH:6][cH:7]1>>[c:2]1([Br:48])[cH:3][c:4]([CH2:18][N:19]2[C:20](=[O:39])[O:21][CH:22]([c:25]3[cH:26][c:27]([C:35]([F:36])([F:37])[F:38])[cH:28][c:29]([C:31]([F:32])([F:33])[F:34])[cH:30]3)[CH:23]2[CH3:24])[c:5](-[c:8]2[c:9]([Cl:17])[cH:10][cH:11][c:12]([CH:14]([CH3:15])[CH3:16])[cH:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 5558BromoformHCID 6344DichloromethaneHCID 10906Tert-Butyl nitriteHCID 730147663-[[5-Amino-2-(2-chloro-5-propan-2-ylphenyl)phenyl]methyl]-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

Product 1

HCID 730057745-[3,5-Bis(trifluoromethyl)phenyl]-3-[[5-bromo-2-(2-chloro-5-propan-2-ylphenyl)phenyl]methyl]-4-methyl-1,3-oxazolidin-2-one

Sources & evidence

ORD record
ord-793dca1f17d34eeea18e52f4e664c34a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…