反应详情

A solution of 4.5 g. of methyl 3-(3-trifluoromethylphenyl)-4-amino-5-isothiazolecarboxylate and 5.1 g. of isoamyl nitrite in 50 ml. of tetrahydrofuran was heated to reflux for one-half hour. The reaction mixture then was cooled, and the solvent was removed by evaporation under reduced pressure to provide a solid product which was crystallized from ethanol and water to give 2.8 g. (66% yield) of methyl 3-(3-trifluoromethylphenyl)-5-isothiazolecarboxylate. M.P. 82°-83° C.

1. temperatureto reflux for one-half hour
2. temperatureThe reaction mixture then was cooled
3. customthe solvent was removed by evaporation under reduced pressure
4. customto provide a solid product which
5. customwas crystallized from ethanol and water
6. customto give 2.8 g