Hydrochloric Acid → {6-[3-(2-Amino-ethyl)-phenyl]-2-methoxy-pyrimidin-4-yl}-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethyl]-amine

HRID 676612Notes

Reaction equation

HRID 676612 reaction equation
[CH3:32][OH:33].[ClH:34].[F:1][c:2]1[c:3]([CH2:12][CH2:13][NH:14][c:15]2[cH:16][c:17](-[c:23]3[cH:24][c:25]([CH2:29][C:30]#[N:31])[cH:26][cH:27][cH:28]3)[n:18][c:19]([O:21][CH3:22])[n:20]2)[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1>>[F:1][c:2]1[c:3]([CH2:12][CH2:13][NH:14][c:15]2[cH:16][c:17](-[c:23]3[cH:24][c:25]([CH2:29][CH2:30][NH2:31])[cH:26][cH:27][cH:28]3)[n:18][c:19]([O:21][CH3:22])[n:20]2)[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 69071559(3-{6-[2-(2-Fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-acetonitrile

Product 1

HCID 69070707{6-[3-(2-Amino-ethyl)-phenyl]-2-methoxy-pyrimidin-4-yl}-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethyl]-amine

Sources & evidence

ORD record
ord-2bb43f81ff634647afdd355c6d401b06
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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