Propanal → HCID 178438255, compound

HRID 67728Notes

Reaction equation

HRID 67728 reaction equation
[CH3:1][NH:2][C:3](=[S:6])[NH:4][NH2:5].[CH:7](=O)[CH2:8][CH3:9].N1C=CC=CC=1.[C:17](Cl)(=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19]>C1(C)C=CC=CC=1>[CH2:8]([CH:9]1[S:6][C:3]([NH:2][CH3:1])=[N:4][N:5]1[C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])[CH3:7]

Participants

6

Reactant 4

HCID 527PropanalHCID 1049PyridineHCID 62493Pivaloyl chlorideHCID 2723853N-Methylhydrazinecarbothioamide

Product 1

HCID 178438255HCID 178438255, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 10.5 g. portion of 4-methylthiosemicarbazide was reacted with 5.8 g. of propionaldehyde in the presence of 7.9 g. of pyridine and 200 ml. of toluene, and 12.1 g. of pivaloyl chloride was added to produce 13.8 g. of the desired product, m.p. 78.5°-80°.

Workup

  1. customto produce 13.8 g

Sources & evidence

ORD record
ord-ba8d6bf00d254426b30add6720239cc1
Source dataset
uspto-grants-1982_08
Patent number
US04346225

Reaction notes

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