Acetone → HCID 178482499, compound

HRID 67729Notes

Reaction equation

HRID 67729 reaction equation
[CH3:1][NH:2][C:3](=[S:6])[NH:4][NH2:5].[CH3:7][C:8]([CH3:10])=O.[F:11][C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15]>N1C=CC=CC=1>[F:11][C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]([N:5]1[C:8]([CH3:10])([CH3:7])[S:6][C:3]([NH:2][CH3:1])=[N:4]1)=[O:15]

Participants

5

Reactant 3

HCID 180AcetoneHCID 98082-Fluorobenzoyl chlorideHCID 2723853N-Methylhydrazinecarbothioamide

Product 1

HCID 178482499HCID 178482499, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 42 g. portion of 4-methylthiosemicarbazide was reacted with 400 ml. of acetone, and then with 32 ml. of pyridine and 63.6 g. of 2-fluorobenzoyl chloride to prepare 66.5 g. of the desired product, m.p. 136°-140°.

Sources & evidence

ORD record
ord-942626b67a8a4711bd9a19d156dd0fc4
Source dataset
uspto-grants-1982_08
Patent number
US04346225

Reaction notes

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