4-(4-Chloro-3-dimethylsulfamoylphenyl)-3-methyl-2-phenyliminothiazolidin-4-ol → Metibride

HRID 67746Notes

Reaction equation

HRID 67746 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2(O)[CH2:12][S:11][C:10](=[N:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:9]2[CH3:20])=[CH:4][C:3]=1[S:22](=[O:27])(=[O:26])[N:23]([CH3:25])[CH3:24]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH3:20])[C:10](=[N:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[S:11][CH:12]=2)=[CH:4][C:3]=1[S:22](=[O:27])(=[O:26])[N:23]([CH3:24])[CH3:25]

Participants

3

Reactant 1

HCID 205273264-(4-Chloro-3-dimethylsulfamoylphenyl)-3-methyl-2-phenyliminothiazolidin-4-ol

Product 1

HCID 3047726Metibride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

8.52 g (0.02 mole) of 4-(4-chloro-3-dimethylsulfamoylphenyl)-3-methyl-2-phenyliminothiazolidin-4-ol in 100 ml of glacial acetic acid are heated at the boil for 3 hours, the solvent is distilled off and the residue is made to crystallize using water. Melting point 180° C.

Workup

  1. distillationthe solvent is distilled off
  2. customto crystallize

Sources & evidence

ORD record
ord-2c83853343d54aa4bb66be59f786f2ba
Source dataset
uspto-grants-1982_08
Patent number
US04346088

Reaction notes

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