Hydrochloric Acid → 2-(4-Fluorophenyl)-3-[2-(3-hydroxypropylamino)-4-pyrimidinyl]-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

HRID 677543Notes

Reaction equation

HRID 677543 reaction equation
[ClH:46].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][n:10]3[c:11]([cH:12][cH:13][c:14]([C:16]([F:17])([F:18])[F:19])[cH:15]3)[c:20]2-[c:21]2[n:22][c:23]([NH:27][CH2:28][CH2:29][CH2:30][O:31][CH2:32][c:33]3[cH:34][cH:35][c:36]([O:37][CH3:38])[cH:39][cH:40]3)[n:24][cH:25][cH:26]2)[cH:6][cH:7]1.[Na+:45].[O-:41][C:42]([OH:43])=[O:44].[O:47]1[CH2:48][CH2:49][O:50][CH2:51][CH2:52]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][n:10]3[c:11]([cH:12][cH:13][c:14]([C:16]([F:17])([F:18])[F:19])[cH:15]3)[c:20]2-[c:21]2[n:22][c:23]([NH:27][CH2:28][CH2:29][CH2:30][OH:31])[n:24][cH:25][cH:26]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 312751,4-DioxaneHCID 210769724-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-N-(3-(4-methoxybenzyloxy)propyl)-2-pyrimidinamine

Product 1

HCID 102030182-(4-Fluorophenyl)-3-[2-(3-hydroxypropylamino)-4-pyrimidinyl]-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

Sources & evidence

ORD record
ord-e079e42f241b41dd8b3110098af54869
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…