HCID 20476837, compound → 2-Bromo-3'-methyl-5'-sulfamoylacetophenone

HRID 67787Notes

Reaction equation

HRID 67787 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:16])(=[O:15])[N:12](C)C)[CH:8]=[CH:7][C:6]=1Br)=[O:4].Br[CH2:19]C(C1C=C(S(=O)(=O)N(C)C)C=C(Cl)C=1)=O.BrCC(C1C=C(S(=O)(=O)NC)C=CC=1Cl)=O.BrCC(C1C=C(S(=O)(=O)N(C)C)C=CC=1Cl)=O.BrCC(C1C=C(S(=O)(=O)N)C=CC=1Cl)=O.BrCC(C1C=C(S(=O)(=O)N(C)C)C=C(C)C=1)=O.BrCC(C1C=C(S(=O)(=O)N(C)C)C=CC=1C)=O.BrCC(C1C=C(S(=O)(=O)N)C=CC=1C)=O>>[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:16])(=[O:15])[NH2:12])[CH:8]=[C:7]([CH3:19])[CH:6]=1)=[O:4]

Participants

9

Reactant 8

HCID 20476837HCID 20476837, compoundHCID 204768412-Bromo-3'-chloro-5'-dimethylsulfamoyl-acetophenoneHCID 205271572-Bromo-2'-chloro-5'-dimethylsulfamoyl-acetophenoneHCID 205273082-Bromo-2'-chloro-5'-sulfamoylacetophenoneHCID 20527387HCID 20527387, compoundHCID 20527402HCID 20527402, compoundHCID 20527440HCID 20527440, compoundHCID 20527473HCID 20527473, compound

Product 1

HCID 205271342-Bromo-3'-methyl-5'-sulfamoylacetophenone

Procedure

The bromoacetophenones listed below were prepared in an analogous manner: 2,2'-dibromo-5'-dimethylsulfamoyl-acetophenone, melting point 88° C., 2-bromo-3'-chloro-5'-dimethylsulfamoyl-acetophenone, melting point 77°-78° C., 2-bromo-2'-chloro-5'-methylsulfamoyl-acetophenone, melting point 99°-101° C., 2-bromo-2'-chloro-5'-dimethylsulfamoyl-acetophenone, melting point 87°-88° C., 2-bromo-2'-chloro-5'-sulfamoylacetophenone, melting point 152°-154° C., 2-bromo-3'-methyl-5'-dimethylsulfamoylacetophenone, melting point 71°-75° C., 2-bromo-2'-methyl-5'-dimethylsulfamoylacetophenone, melting point 69°-71° C. and 2-bromo-2'-methyl-5'-sulfamoylacetophenone, melting point 112°-115° C.

Workup

  1. custombelow were prepared in an analogous manner

Sources & evidence

ORD record
ord-e9deda43a70e4259ab4aa93b071fa763
Source dataset
uspto-grants-1982_08
Patent number
US04346088

Reaction notes

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