Dimethylformamide → Tert-butyl 3-[4-[6-amino-5-[1-(2,3-difluoro-4-methoxyphenyl)tetrazol-5-yl]-3-pyridinyl]pyrazol-1-yl]piperidine-1-carboxylate

HRID 677896Notes

Reaction equation

HRID 677896 reaction equation
[Br:28][c:29]1[cH:30][c:31](-[c:36]2[n:37][n:38][n:39][n:40]2-[c:41]2[c:42]([F:50])[c:43]([F:49])[c:44]([O:47][CH3:48])[cH:45][cH:46]2)[c:32]([NH2:35])[n:33][cH:34]1.[CH3:1][C:2]1([CH3:3])[C:4]([CH3:5])([CH3:6])[O:7][B:8]([c:9]2[cH:10][n:11][n:12]([CH:14]3[CH2:15][N:16]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:17][CH2:18][CH2:19]3)[cH:13]2)[O:27]1.[O:51]=[CH:52][N:53]([CH3:54])[CH3:55]>>[c:9]1(-[c:29]2[cH:30][c:31](-[c:36]3[n:37][n:38][n:39][n:40]3-[c:41]3[c:42]([F:50])[c:43]([F:49])[c:44]([O:47][CH3:48])[cH:45][cH:46]3)[c:32]([NH2:35])[n:33][cH:34]2)[cH:10][n:11][n:12]([CH:14]2[CH2:15][N:16]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:17][CH2:18][CH2:19]2)[cH:13]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 582937635-bromo-3-(1-(2,3-difluoro-4-methoxyphenyl)-1H-tetrazol-5-yl)pyridin-2-amineHCID 59392634tert-butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Product 1

HCID 67027065Tert-butyl 3-[4-[6-amino-5-[1-(2,3-difluoro-4-methoxyphenyl)tetrazol-5-yl]-3-pyridinyl]pyrazol-1-yl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-b56a6a8c0ccf47a4ba233431b6eac794
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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