Dichloromethane → Trifluoroacetic acid

HRID 678120Notes

Reaction equation

HRID 678120 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH2:8][CH:9]1[CH2:10][N:11]([c:15]2[cH:16][c:17]3[c:21]([c:22]([F:24])[cH:23]2)[N:20]([CH2:25][CH:26]2[CH2:27][CH2:28]2)[C:19](=[O:29])[CH2:18]3)[C:12](=[O:14])[O:13]1)([CH3:5])([CH3:6])[CH3:30].[Cl:38][CH2:39][Cl:40].[F:31][C:32]([C:33](=[O:34])[OH:35])([F:36])[F:37]>>[F:31][C:32]([C:33](=[O:34])[OH:35])([F:36])[F:37].[NH2:7][CH2:8][CH:9]1[CH2:10][N:11]([c:15]2[cH:16][c:17]3[c:21]([c:22]([F:24])[cH:23]2)[N:20]([CH2:25][CH:26]2[CH2:27][CH2:28]2)[C:19](=[O:29])[CH2:18]3)[C:12](=[O:14])[O:13]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 69272819tert-butyl N-[[3-[1-(cyclopropylmethyl)-7-fluoro-2-oxo-3H-indol-5-yl]-2-oxo-1,3-oxazolidin-5-yl]methyl]carbamate

Product 2

HCID 6422Trifluoroacetic acidHCID 692741635-(aminomethyl)-3-[1-(cyclopropylmethyl)-7-fluoro-2-oxo-3H-indol-5-yl]-1,3-oxazolidin-2-one

Sources & evidence

ORD record
ord-85bd0aacd870492281beeac8a3802c60
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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