Dichloromethane → 2-(2-Chloro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)acetaldehyde

HRID 678232Notes

Reaction equation

HRID 678232 reaction equation
[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[CH2:6][CH2:7][C:8]3([CH2:9][N:10]([C:14](=[O:15])[c:16]4[n:17][c:18]([CH:21]([CH3:22])[CH3:23])[s:19][cH:20]4)[CH2:11][CH2:12][O:13]3)[CH2:24][CH2:25]2)[cH:26][cH:27][cH:28][c:29]1[CH2:30][CH2:31][OH:32].[Cl:40][CH2:41][Cl:42].[OH:33][C:34]([C:35]([F:36])([F:37])[F:38])=[O:39]>>[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[CH2:6][CH2:7][C:8]3([CH2:9][N:10]([C:14](=[O:15])[c:16]4[n:17][c:18]([CH:21]([CH3:22])[CH3:23])[s:19][cH:20]4)[CH2:11][CH2:12][O:13]3)[CH2:24][CH2:25]2)[cH:26][cH:27][cH:28][c:29]1[CH2:30][CH:31]=[O:32]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 46240302(9-(2-Chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Product 1

HCID 579889712-(2-Chloro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)acetaldehyde

Sources & evidence

ORD record
ord-5a628640bf334dd3af6209debad351b1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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