Dichloromethane → [8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(1-piperidin-4-yl-1H-pyrazol-4-yl)-amine

HRID 678262Notes

Reaction equation

HRID 678262 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][cH:16][c:17]([NH:19][c:20]3[n:21][n:22]4[c:23]([c:24](-[c:28]5[cH:29][cH:30][c:31]([S:34](=[O:35])(=[O:36])[CH3:37])[cH:32][cH:33]5)[cH:25][cH:26][cH:27]4)[n:38]3)[cH:18]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:46][CH2:47][Cl:48].[OH:39][C:40]([C:41]([F:42])([F:43])[F:44])=[O:45]>>[NH:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][cH:16][c:17]([NH:19][c:20]3[n:21][n:22]4[c:23]([c:24](-[c:28]5[cH:29][cH:30][c:31]([S:34](=[O:35])(=[O:36])[CH3:37])[cH:32][cH:33]5)[cH:25][cH:26][cH:27]4)[n:38]3)[cH:18]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 674813844-{4-[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-ylamino]-pyrazol-1-yl}-piperidin-1-carboxylic acid tert-butyl ester

Product 1

HCID 67481518[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(1-piperidin-4-yl-1H-pyrazol-4-yl)-amine

Sources & evidence

ORD record
ord-8322895360874a759ce4bcf57f4736d6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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