Sodium ion → 8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-imidazo[1,2-a][1,4]benzodiazepine-2-methanol

HRID 678539Notes

Reaction equation

HRID 678539 reaction equation
[Al:1].[Cl:4][c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:30]1)[C:10]([c:23]1[c:24]([F:29])[cH:25][cH:26][cH:27][cH:28]1)=[N:11][CH2:12][c:13]1[n:14]-2[c:15]([CH3:22])[c:16]([C:18](=[O:19])[O:20][CH3:21])[n:17]1.[H-:3].[Li:2].[Na+:32].[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1.[OH-:31].[OH2:38]>>[Cl:4][c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:30]1)[C:10]([c:23]1[c:24]([F:29])[cH:25][cH:26][cH:27][cH:28]1)=[N:11][CH2:12][c:13]1[n:14]-2[c:15]([CH3:22])[c:16]([CH2:18][OH:19])[n:17]1

Participants

9

Reactant 8

HCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 166653HydrideHCID 3028194LithiumHCID 5359268AluminumHCID 21266007methyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,2-a][1,4]benzodiazepine-2-carboxylate

Product 1

HCID 212660038-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-imidazo[1,2-a][1,4]benzodiazepine-2-methanol

Sources & evidence

ORD record
ord-b1db625740964cefb5b7c23f86462a36
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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