Chloroform → 4-(6-Iodo-quinazolin-4-yl)-piperidine-1-carboxylic acid (4-isopropoxy-phenyl)-amide

HRID 678546Notes

Reaction equation

HRID 678546 reaction equation
[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[Cl:50][CH:51]([Cl:52])[Cl:53].[I:1][c:2]1[cH:3][c:4]2[c:5]([CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[n:6][cH:7][n:8][c:9]2[cH:10][cH:11]1.[N+:18]([c:19]1[cH:20][cH:21][c:22]([O:27][C:28](=[O:23])[NH:29][c:30]2[cH:31][cH:32][c:33]([O:36][CH:37]([CH3:38])[CH3:39])[cH:34][cH:35]2)[cH:24][cH:25]1)([O-:26])=[O:40]>>[I:1][c:2]1[cH:3][c:4]2[c:5]([CH:12]3[CH2:13][CH2:14][N:15]([C:28](=[O:27])[NH:29][c:30]4[cH:31][cH:32][c:33]([O:36][CH:37]([CH3:38])[CH3:39])[cH:34][cH:35]4)[CH2:16][CH2:17]3)[n:6][cH:7][n:8][c:9]2[cH:10][cH:11]1

Participants

5

Reactant 4

HCID 6212ChloroformHCID 81531DiisopropylethylamineHCID 58769998(4-Isopropoxy-phenyl)-carbamic acid 4-nitrophenyl esterHCID 587708326-Iodo-4-piperidin-4-yl-quinazoline

Product 1

HCID 587706604-(6-Iodo-quinazolin-4-yl)-piperidine-1-carboxylic acid (4-isopropoxy-phenyl)-amide

Sources & evidence

ORD record
ord-521aba2a386d4961aa642b5d36569a09
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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