反应详情

2 parts of [(tetrahydro-2H-pyran-2-ylidene)methyl] triphenylphosphonium chloride and 1.85 parts of 3-bromobenzaldehyde were combined in 45 parts of xylene. This was maintained under a nitrogen atmosphere and was refluxed for 3 hours. After the reaction mixture was cooled to room temperature, xylene was removed at a temperature of about 60° C. and under reduced pressure, leaving a product mixture. This mixture was separated chromatographically on a silica column using benzene as the elution solvent, to yield 1-(3-bromophenyl)-7-chloro-1-hepten-3-one.

1. temperatureThis was maintained under a nitrogen atmosphere
2. temperaturewas refluxed for 3 hours
3. customxylene was removed at a temperature of about 60° C. and under reduced pressure
4. customleaving a product mixture
5. customThis mixture was separated chromatographically on a silica column