反应详情

The product (208 mg, 1.0 mmol) from Step B and piperidine (0.5 mL, 5 mmol) were mixed in absolute ethanol (3 mL) and then heated at reflux for 4 h. The reaction mixture was cooled to r.t., and the solvent removed under vacuum. The solids were taken up in EtOAc (125 mL). The mixture was transferred to a separatory funnel and washed with water (3×15 mL). The organic layer was dried over sodium sulfate, filtered and the solvent removed under vacuum to afford the product as a yellow solid, MS: m/z 258 (MH+) which was used without further purification.

1. temperatureheated
2. temperatureat reflux for 4 h
3. customthe solvent removed under vacuum
4. customThe mixture was transferred to a separatory funnel
5. washwashed with water (3×15 mL)
6. dry with materialThe organic layer was dried over sodium sulfate
7. filtrationfiltered
8. customthe solvent removed under vacuum