Methylamine → HCID 178485064, compound

HRID 67988Notes

Reaction equation

HRID 67988 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15](=[N:18][C:19]#[N:20])OC)[N:9]=1)[C:2]([NH2:4])=[NH:3].[CH3:21][NH2:22]>O>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]([NH:22][CH3:21])=[N:18][C:19]#[N:20])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178496794HCID 178496794, compound

Product 1

HCID 178485064HCID 178485064, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-guanidino-4-[2-(3-cyano-2-methylisoureido)ethylthiomethyl]thiazole (1.88 g.) and 30% w/v aqueous methylamine (6.0 ml.) was stirred together at room temperature. After 1 hour 40 minutes water (20 ml.) was added, and stirring was continued for 15 minutes. The white solid (1.265 g.) was collected, washed with water (3 ml.) and dried in vacuo overnight. Recrystallization from aqueous dimethylformamide gave 2-guanidino-4-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]thiazole, m.p. 160°-161.5° C.

Workup

  1. stirringstirring
  2. customThe white solid (1.265 g.) was collected
  3. washwashed with water (3 ml.)
  4. customdried in vacuo overnight
  5. customRecrystallization from aqueous dimethylformamide

Sources & evidence

ORD record
ord-1c1dcee896664c62a031c0213b2a9c9f
Source dataset
uspto-grants-1982_08
Patent number
US04347370

Reaction notes

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