HRID67990

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

$结构：CN=C(NCCSCc1csc(NC(=N)N)n1)SC.I.O=C(O)/C=C\C(=O)O$

HCID178484986

未命名化合物

PRODUCTS

生成物

$结构：CNC(=O)NCCSCc1csc(NC(=N)N)n1.CNC(=O)NCCSCc1csc(NC(=N)N)n1.O.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O$

HCID178485939

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of 2-guanidino-4-[2-(2,3-dimethylisothioureido)ethylthiomethyl]thiazole hydrogen maleate hydriodide (0.8 g.) in water (10 ml.) was treated with an aqueous solution of potassium carbonate (0.3 g. in 5 ml. water) and the solution heated on the steam bath for 4 hours. After cooling and allowing to stand for 16 hours the aqueous layer was decanted from the brown gum and the gum taken up into ethanol and filtered. The filtrate was evaporated to dryness and the residue converted to the hydrogen maleate salt which was recrystallized from ethanol to give 2-guanidino-4-[2-(3-methylureido)ethylthiomethyl]thiazole hydrogen maleate hemihydrate, m.p. 167°-170° C.

WORKUP

后处理

temperaturethe solution heated on the steam bath for 4 hours
temperatureAfter cooling
customthe aqueous layer was decanted from the brown gum
filtrationfiltered
customThe filtrate was evaporated to dryness
customwas recrystallized from ethanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-47dc66d9d66c46cd94d394fc1df9c5e3
来源数据集: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04347370
来源说明: uspto-grants-1982_08

反应 SMILES

I.[C:2]([OH:9])(=[O:8])/[CH:3]=[CH:4]\[C:5]([OH:7])=[O:6].[NH:10]([C:14]1[S:15][CH:16]=[C:17]([CH2:19][S:20][CH2:21][CH2:22][NH:23][C:24](=[N:27][CH3:28])SC)[N:18]=1)[C:11]([NH2:13])=[NH:12].C(=O)([O-])[O-:30].[K+].[K+]>O>[OH2:6].[C:2]([OH:9])(=[O:8])/[CH:3]=[CH:4]\[C:5]([OH:7])=[O:6].[NH:10]([C:14]1[S:15][CH:16]=[C:17]([CH2:19][S:20][CH2:21][CH2:22][NH:23][C:24]([NH:27][CH3:28])=[O:30])[N:18]=1)[C:11]([NH2:13])=[NH:12].[NH:10]([C:14]1[S:15][CH:16]=[C:17]([CH2:19][S:20][CH2:21][CH2:22][NH:23][C:24]([NH:27][CH3:28])=[O:6])[N:18]=1)[C:11]([NH2:13])=[NH:12].[C:2]([OH:9])(=[O:8])/[CH:3]=[CH:4]\[C:5]([OH:7])=[O:6]