Potassium Carbonate → HCID 178485939, compound

HRID 67990Notes

Reaction equation

HRID 67990 reaction equation
I.[C:2]([OH:9])(=[O:8])/[CH:3]=[CH:4]\[C:5]([OH:7])=[O:6].[NH:10]([C:14]1[S:15][CH:16]=[C:17]([CH2:19][S:20][CH2:21][CH2:22][NH:23][C:24](=[N:27][CH3:28])SC)[N:18]=1)[C:11]([NH2:13])=[NH:12].C(=O)([O-])[O-:30].[K+].[K+]>O>[OH2:6].[C:2]([OH:9])(=[O:8])/[CH:3]=[CH:4]\[C:5]([OH:7])=[O:6].[NH:10]([C:14]1[S:15][CH:16]=[C:17]([CH2:19][S:20][CH2:21][CH2:22][NH:23][C:24]([NH:27][CH3:28])=[O:30])[N:18]=1)[C:11]([NH2:13])=[NH:12].[NH:10]([C:14]1[S:15][CH:16]=[C:17]([CH2:19][S:20][CH2:21][CH2:22][NH:23][C:24]([NH:27][CH3:28])=[O:6])[N:18]=1)[C:11]([NH2:13])=[NH:12].[C:2]([OH:9])(=[O:8])/[CH:3]=[CH:4]\[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 1784849862-Guanidino-4-[2-(2,3-dimethylisothioureido)ethylthiomethyl]thiazole hydrogen maleate hydriodide

Product 1

HCID 178485939HCID 178485939, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2-guanidino-4-[2-(2,3-dimethylisothioureido)ethylthiomethyl]thiazole hydrogen maleate hydriodide (0.8 g.) in water (10 ml.) was treated with an aqueous solution of potassium carbonate (0.3 g. in 5 ml. water) and the solution heated on the steam bath for 4 hours. After cooling and allowing to stand for 16 hours the aqueous layer was decanted from the brown gum and the gum taken up into ethanol and filtered. The filtrate was evaporated to dryness and the residue converted to the hydrogen maleate salt which was recrystallized from ethanol to give 2-guanidino-4-[2-(3-methylureido)ethylthiomethyl]thiazole hydrogen maleate hemihydrate, m.p. 167°-170° C.

Workup

  1. temperaturethe solution heated on the steam bath for 4 hours
  2. temperatureAfter cooling
  3. customthe aqueous layer was decanted from the brown gum
  4. filtrationfiltered
  5. customThe filtrate was evaporated to dryness
  6. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-47dc66d9d66c46cd94d394fc1df9c5e3
Source dataset
uspto-grants-1982_08
Patent number
US04347370

Reaction notes

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