Lithium ion → 6-{1-[2-(2-Methylquinolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-3,4-dihydro-2H-benzo[1,4]oxazine

HRID 679945Notes

Reaction equation

HRID 679945 reaction equation
[Al+3:34].[CH3:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][c:8]([O:12][CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([CH2:21][c:22]4[cH:23][cH:24][c:25]5[c:26]([cH:32]4)[NH:27][C:28](=[O:31])[CH2:29][O:30]5)[CH2:19][CH2:20]3)[c:9]2[cH:10][cH:11]1.[H-:33].[H-:36].[H-:37].[H-:38].[Li+:35]>>[CH3:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][c:8]([O:12][CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([CH2:21][c:22]4[cH:23][cH:24][c:25]5[c:26]([cH:32]4)[NH:27][CH2:28][CH2:29][O:30]5)[CH2:19][CH2:20]3)[c:9]2[cH:10][cH:11]1

Participants

5

Reactant 4

HCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 10296414SB-649,915

Product 1

HCID 103099686-{1-[2-(2-Methylquinolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-3,4-dihydro-2H-benzo[1,4]oxazine

Sources & evidence

ORD record
ord-34955db081cd4bd2ab7c7c47cabf9167
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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