HCID 69593882, compound → HCID 22018869, compound

HRID 6801Notes

Reaction equation

HRID 6801 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[N:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[CH:5][CH:4]=1>CO.[Pd]>[F:18][C:2]([F:1])([F:19])[C:3]1[N:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([O:13][C:14]([CH3:15])([CH3:17])[CH3:16])=[O:12])=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 69593882HCID 69593882, compound

Product 1

HCID 22018869HCID 22018869, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The product of Step C (2.2 g, 8.1 mmol) in 40 mL methanol and 5% palladium on carbon (0.25 g) was stirred under hydrogen atmosphere (balloon) for 1 h. The reaction mixture was filtered through filter aid and the solvent removed under vacuum to afford the product as a solid, MS: m/z 276 (MH+).

Workup

  1. filtrationThe reaction mixture was filtered
  2. filtrationthrough filter aid
  3. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-88fe29ea69b54e5088b5bb28e789c315
Source dataset
uspto-grants-2006_08
Patent number
US07084156B2

Reaction notes

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