反应详情

温度

40 °C

A mixture of ethyl 3-(chloro-4-cyanophenyl)propanoate (33.0 g, 0.14 mol), KOH (6.27 g, 0.11 mol) and 95% ethanol (109 mL) was warmed at 40° C. for 1 h. The mixture was neutralized and evaporated to dryness. The residue was dissolved in 5% NaHCO3 and washed with EtOAc. Acidification and filtration gave crystalline 3-(2-chloro-4-cyanophenyl) propanoic acid: 18.4 g; mp 127°-219° C.

1. customevaporated to dryness
2. dissolutionThe residue was dissolved in 5% NaHCO3
3. washwashed with EtOAc
4. filtrationAcidification and filtration