HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 68027Generated: October 29, 2026
Potassium Hydroxide → 3-(2-Chloro-4-cyanophenyl)propanoic acid
https://huagongshe.com/reaction/68027
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 3-(chloro-4-cyanophenyl)propanoate | HCID 13042095 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2-Chloro-4-cyanophenyl)propanoic acid | HCID 13042096 | — |
Reaction Steps
A mixture of ethyl 3-(chloro-4-cyanophenyl)propanoate (33.0 g, 0.14 mol), KOH (6.27 g, 0.11 mol) and 95% ethanol (109 mL) was warmed at 40° C. for 1 h. The mixture was neutralized and evaporated to dryness. The residue was dissolved in 5% NaHCO3 and washed with EtOAc. Acidification and filtration gave crystalline 3-(2-chloro-4-cyanophenyl) propanoic acid: 18.4 g; mp 127°-219° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04347382 |
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| Source dataset | uspto-grants-1982_08 |
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| ORD ID | ord-a8ff8187a948457790302e84f15453e1 |
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| Source note | uspto-grants-1982_08 |
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