Dichloromethane → Tert-butyl 4-(2-fluorobenzoyl)piperazine-1-carboxylate

HRID 680483Notes

Reaction equation

HRID 680483 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[CH2:14]([N:15]([CH2:16][CH3:17])[CH2:18][CH3:19])[CH3:20].[Cl:31][CH2:32][Cl:33].[F:21][c:22]1[c:23]([C:24](=[O:25])[Cl:26])[cH:27][cH:28][cH:29][cH:30]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([C:24]([c:23]2[c:22]([F:21])[cH:30][cH:29][cH:28][cH:27]2)=[O:25])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 98082-Fluorobenzoyl chlorideHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 4863006Tert-butyl 4-(2-fluorobenzoyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-57755a12f0ed4f22bd8356c8ba5fbf3f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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